A Convenient One-Step Method of Converting Electron-Rich Aromatic Aldehydes into Nitriles

Authors:
  • HSHitomi Suzuki
    Hitomi Suzuki
  • CNChie Nakaya
    Chie Nakaya
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Abstract
Electron-rich aromatic aldehydes react with sodium azide in the presence of aluminum chloride in boiling tetrahydrofuran to give the corresponding nitriles in good yields, while electron-deficient or hindered aromatic aldehydes lead to (diazidomethyl)arenes in moderate yield under similar conditions.