The effect of positive end expiratory pressure on the respiratory profile during one‐lung ventilation for thoracotomy*

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Abstract
Summary: In this randomised controlled trial we examined the effects of four different levels of positive end expiratory pressure (PEEP at 0, 5, 8 or 10 cmH 2 O), added to the dependent lung, on respiratory profile and oxygenation during one lung ventilation. Forty‐six patients were recruited to receive one of the randomised PEEP levels during one lung ventilation. We did not find significant differences in lung compliance, intra‐operative or postoperative oxygenation amongst the four different groups. However, the physiological deadspace to tidal volume ventilation ratio was significantly lower in the 8 cmH 2 O PEEP group compared with the other levels of PEEP (p < 0.0001). We concluded that the use of PEEP (≤10 cmH 2 O) during one lung ventilation does not clinically improve lung compliance, intra‐operative or postoperative oxygenation despite a statistically significant reduction in the physiological deadspace to tidal volume ratio.

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