Biosynthesis of XR587 (streptopyrrole) in Streptomyces rimosus involves a novel carbon-to-nitrogen rearrangement of a proline-derived unit

Authors:
  • MRMairi E. Raggatt
    Mairi E. Raggatt
  • TSThomas J. Simpson
    Thomas J. Simpson
  • SWStephen K. Wrigley
    Stephen K. Wrigley
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Abstract
Results from incorporation studies with 13C-labelled acetate, propionate and proline establish a polyketide origin for the pyrrole-containing streptomycete metabolite, XR587, and are in accord with the formation of an amide bond via an unprecedented rearrangement of a proline-derived starter unit.
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