Interferon Suppresses Sympathetic Neuronal Cell Death Caused by Nerve Growth Factor Deprivation
Authors:
- 1 August 1990
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 55 (2) , 436-445
Abstract
Cultured rat sympathetic neurons die within 48 h after being deprived of nerve growth factor. Addition of interferons (IFN‐α/β or IFN‐γ) prevented the cell death in a dose‐dependent manner. Upon longer periods of nerve growth factor deprivation, IFNs failed to maintain survival. Thus, IFNs retarded neuronal death, but did not prevent it. Ligand binding, autoradiography, and cross‐linking experiments demonstrated the presence of specific IFN‐γ receptors on sympathetic neurons similar to those seen on other cell types. The possible relationships of the death‐suppressing actions of IFNs are compared to the mechanisms of the antiviral or antiproliferative actions of IFNs.Keywords
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