Dynamic instability in nanoscale lipid domains revealed by contact mode high speed AFM: effect of amyloid-β and cholesterol content

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Abstract
This study uses contact-mode HS-AFM to probe Aβ interactions with neuronal lipid models, demonstrating oligomer-induced bilayer destabilization, especially in low-cholesterol membranes, emphasizing lipid composition and Aβ species dependent damage.
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Funding Information
  • Mitacs (Globalink Research Internship)
  • Bristol Centre for Functional Nanomaterials, University of Bristol (Collaborative Initiative Grant)
  • Waterloo Institute for Nanotechnology, University of Waterloo (International Strategic Partnership Grant)
  • Waterloo Institute for Nanotechnology, University of Waterloo (Graduate Nanofellowship)
  • Natural Sciences and Engineering Research Council of Canada (NSERC IRPG 5050311497)
  • Natural Sciences and Engineering Research Council of Canada (NSERC Undergraduate Student Research Award (USRA))

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