Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis
Authors:
Open Access
- 28 August 2007
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 97 (6) , 792-801
Abstract
To characterise Ca2+-binding protein gene expression changes in oral squamous cell carcinomas (OSCCs), we compared the gene expression profiles in OSCC-derived cell lines with normal oral tissues. One hundred Ca2+-binding protein genes differentially expressed in OSCCs were identified, and genetic pathways associated with expression changes were generated. Among genes mapped to the network with the highest significance, glucose-regulated protein 94 kDa (Grp94) was evaluated further for mRNA and protein expression in the OSCC cell lines, primary OSCCs, and oral premalignant lesions (OPLs). A significant (PP<0.001) correlated with poor disease-free survival. The results suggested that Grp94 may have potential clinical application as a novel diagnosis and prognostic biomarker for human OSCCs.Keywords
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