Propolis ameliorates restenosis in hypercholesterolemia rabbits with carotid balloon injury by inhibiting lipid accumulation, oxidative stress, and TLR4/NF‐κB pathway

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Abstract
Neointima formation and atherosclerosis are the main complications after the endovascular intervention and vascular surgery, and there are no effective drugs. Propolis is a kind of resin substance produced by honeybees and has numerous health‐beneficial effects. In this study, we evaluated the effects of propolis (125 and 250 mg·kg–1·day–1, 6 weeks) on carotid restenosis in hypercholesterolemia rabbits. Propolis significantly ameliorated the degree of carotid restenosis, inhibited neointima hyperplasia, reduced serum lipids profile, and enhanced the anti‐oxidative activities in hypercholesterolemia rabbits. Furthermore, propolis reduced the plasma levels of C‐reactive protein, interleukin‐6, and tumor necrosis factor‐α (TNF‐α), and inhibited the expression of CD68, TLR4, NF‐κB p65, MMP‐9, and TNF‐α in the carotid arteries. The results indicate that propolis has a protective effect on carotid restenosis in rabbits, which is associated with regulating blood lipids, inhibiting oxidative stress and inflammation, and its anti‐inflammatory activity may be related to inhibit TLR4‐mediated NF‐κB signaling pathway. Practical applications Restenosis is a primary challenge in angioplasty and atherosclerotic treatment. Hyperlipidemia can induce inflammation and accelerate the formation of restenosis. Recently, natural products have been widely used to prevent intimal hyperplasia of common cardiovascular diseases. Propolis is currently a popular functional food, but the role of propolis on carotid restenosis after angioplasty and its underlying mechanism remains unclear. This study showed that propolis inhibits the effect of carotid restenosis in hypercholesterolemia rabbits. The results of this study may provide a basis for propolis to prevent and treat vascular restenosis.

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