Photonic probing of structural alterations in DNA specific mass density fluctuations in nuclei due to total body irradiation (TBI) via confocal imaging

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Abstract
Abnormalities within cells result in intracellular structural alterations ranging from nano to submicron scales. Accidental or deliberate exposure to total body irradiation has adverse effects on the nuclear DNAs of cells. Here, we study the molecular specific DNA spatial mass density fluctuations of chromatin of mice gut cell nuclei caused by the exposure to standard doses of 4-Gy total body irradiation, using the light localization technique called inverse participation ratio via confocal imaging. Results show radiation suppresses DNA spatial mass density fluctuations. And hence, the reduction and saturation in DNA mass density fluctuations are observed on different durations of post-irradiation.
Funding Information
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIH DK55532)

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