Leveraging the predictive power of 3D organoids in dogs to develop new treatments for man and man’s best friend
Open Access
- 29 December 2023
- journal article
- editorial
- Published by Springer Nature in BMC Biology
- Vol. 21 (1) , 1-5
Abstract
Recent progress in adult stem cell technology, along with interdisciplinary collaboration in the field of One Health, has accelerated the development of 3D organoid cultures in non-model animals, such as dogs. These advancements have the potential to significantly impact disease modeling and drug development for many diseases shared between man and man’s best friend.Keywords
This publication has 11 references indexed in Scilit:
- Development of an Anti-canine PD-L1 Antibody and Caninized PD-L1 Mouse Model as Translational Research Tools for the Study of Immunotherapy in HumansCancer Research Communications, 2023
- A living biobank of canine mammary tumor organoids as a comparative model for human breast cancerScientific Reports, 2022
- Canine Intestinal Organoids in a Dual-Chamber Permeable Support SystemJournal of Visualized Experiments, 2022
- Why 90% of clinical drug development fails and how to improve it?Acta Pharmaceutica Sinica B, 2022
- Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical ResearchJournal of Visualized Experiments, 2022
- Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapyCancer Communications, 2021
- Improving human cancer therapy through the evaluation of pet dogsNature Reviews Cancer, 2020
- Naturally-Occurring Invasive Urothelial Carcinoma in Dogs, a Unique Model to Drive Advances in Managing Muscle Invasive Bladder Cancer in HumansFrontiers in Oncology, 2020
- Establishment of a novel experimental model for muscle‐invasive bladder cancer using a dog bladder cancer organoid cultureCancer Science, 2019
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheNature, 2009