Imidazo-Pyridines
- 3 January 2025
- book chapter
- Published by IGI Global Scientific Publishing
- p. 435-494
Abstract
The structural resemblance between the fused imidazopyridine heterocyclic ring system (a purine system) has prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions. In recent years, new preparative methods for the synthesis of imidazopyridines using various catalysts or non-catalytic systems have been described. In the present chapter, we summarise the recent approaches adopted for the synthesis of functionalized imidazo-pyridines over the last two decades along with their clinical advancement and applications. The key points adopted here including, traditional cyclo-condensation, reaction with nitro olefins, reaction with alkynes, 3-CCR (3-Component Condensation Reaction) based MCRs and miscellaneous aspects of imidazo-pyridine along with its biological importance have been presented and discussed. This chapter will provide new initiatives to the chemists towards the synthesis of imidazo-pyridines and possible medicinal applications with the reported methods.Keywords
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