Ruthenium-Catalyzed Alkylation of Oxindole with Alcohols
Authors:
- 16 April 2009
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 74 (10) , 3990-3992
Abstract
An atom-economical and solvent-free catalytic procedure for the mono-3-alkylation of oxindole with alcohols is described. The reaction is mediated by the in situ generated catalyst from RuCl3·xH2O and PPh3 in the presence of sodium hydroxide. The reactions proceed in good to excellent yields with a wide range of aromatic, heteroaromatic, and aliphatic alcohols.Keywords
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