Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acid
- 24 March 2011
- journal article
- Published by Pleiades Publishing Ltd in Neurochemical Journal
- Vol. 5 (1) , 42-46
Abstract
We developed a new experimental model of oxidative stress in rats, which combines the effects of 3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protective effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant carnosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas carnosine is also effective under conditions of elevated homocysteine level.Keywords
This publication has 19 references indexed in Scilit:
- The excitotoxic effect of NMDA on human lymphocyte immune functionNeurochemistry International, 2007
- Effects of maternal hyperhomocysteinemia induced by high methionine diet on the learning and memory performance in offspringInternational Journal of Developmental Neuroscience, 2007
- Protective activation of the endocannabinoid system during ischemia in dopamine neuronsNeurobiology of Disease, 2006
- Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementiaFEBS Letters, 2006
- Emerging evidence for a similar role of glutamate receptors in the nervous and immune systemsJournal of Neurochemistry, 2005
- Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's DiseaseNew England Journal of Medicine, 2002
- Homocysteine, Alzheimer’s disease, and cognitive functionNutrition, 2000
- Ischemic Cell Death in Brain NeuronsPhysiological Reviews, 1999
- l-Homocysteic acid selectively activates receptors of rat retinal ganglion cellsNeuroscience Letters, 1992
- A new model of bilateral hemispheric ischemia in the unanesthetized rat.Stroke, 1979