Unraveling the Exosome-miR-133a Axis: Targeting TGF-β Signaling via WJ-MSC-Derived Exosomes for Anti-Fibrotic Therapy in Liver Fibrosis
Open Access
- 1 September 2024
- journal article
- Published by Apex Publishing in Iranian Biomedical Journal
- Vol. 28 (5) , 235-244
Abstract
Background: One of the primary drivers of liver fibrosis is the excessive accumulation of extracellular matrix (ECM), primarily caused by the over-proliferation of hepatic star-shaped cells (HSCs). The activation of HSCs by transforming growth factor beta (TGF-β) has a critical role in initiating fibrosis. Recent studies have suggested that miRNA-133a significantly ...Keywords
This publication has 44 references indexed in Scilit:
- Hepatic fibrogenesis2024
- The novel insights of epithelial-derived exosomes in various fibrotic diseasesBiomedicine & Pharmacotherapy, 2024
- Effect of CD44 signal axis in the gain of mesenchymal stem cell surface antigens from synovial fibroblasts in vitroHeliyon, 2022
- Comparison of the effects of cholesterol, palmitic acid, and glucose on activation of human hepatic stellate cells to induce liver fibrosisJournal of Diabetes & Metabolic Disorders, 2022
- Exosomes of lipopolysaccharide-stimulated chicken macrophages modulate immune response through the MyD88/NF-κB signaling pathwayDevelopmental & Comparative Immunology, 2021
- Targeting Oxidative Stress for the Treatment of Liver Fibrosis2018
- Immune responses of human dental pulp stem cells in lipopolysaccharide‐induced microenvironmentCell Biology International, 2018
- Recombinant adeno‐associated virus–mediated inhibition of microRNA‐21 protects mice against the lethal schistosome infection by repressing both IL‐13 and transforming growth factor beta 1 pathwaysHepatology, 2014
- MicroRNA‐101 suppresses liver fibrosis by targeting the TGFβ signalling pathwayThe Journal of Pathology, 2014
- Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesisHepatology, 2012