Target search on DNA -- effect of coiling
Authors:
- Michael A. LomholtMLMichael A. Lomholt
- Ralf MetzlerRMRalf Metzler
Preprint
Abstract
Some proteins can find their targets on DNA faster than by pure diffusion in the three-dimensional cytoplasm, through the process of facilitated diffusion: They can loosely bind to DNA and temporarily slide along it, thus being guided by the DNA molecule itself to the target. This chapter examines this process in mathematical detail with a focus on including the effect of DNA coiling on the search process.Keywords
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