Suppression of Phytohemagglutinin Response by Fungi from a “Leukemia” House
Authors:
- Betty B. WrayBWBetty B. Wray
- Elisabeth J. RushingERElisabeth J. Rushing
- Rebecca C. BoydRBRebecca C. Boyd
- Ann M. SchindelASAnn M. Schindel
- 1 September 1979
- journal article
- research article
- Published by Taylor & Francis in Archives of Environmental Health: An International Journal
- Vol. 34 (5) , 350-353
Abstract
Fungal isolates from the house of a husband and wife who both developed acute myelomonocytic leukemia were assayed for effects on the in vivo response to phytohemagglutinin in guinea pigs. Skin responses to intradermal phytohemagglutinin were measured following injections of sterile fungal extracts. Isolates of Penicillium canescens, Curvularia, Fmarium sambucinum, Fusarium equiseti and Trichoderma koningii from the leukemia-associated house depressed the responses to phytohemagglutinin, but none of the fungal isolates obtained from a nearby control house depressed responses to phytohemagglutinin. Such environmental agents may contribute to development of malignancy by suppression of immune responses.Keywords
This publication has 14 references indexed in Scilit:
- Aflatoxin—Human Colon Carcinogenesis?Annals of Internal Medicine, 1976
- Mycotoxin-Producing Fungi From House Associated With LeukemiaArchives of Environmental Health: An International Journal, 1975
- RISK OF CANCER IN RENAL-TRANSPLANT RECIPIENTSThe Lancet, 1973
- Rat Colon Carcinomas Associated with Aflatoxin and Marginal Vitamin A 2 3JNCI: Journal of the National Cancer Institute, 1973
- Aflatoxins. Potent food poisons and carcinogenic compoundsJournal of Chemical Education, 1972
- Dietary aflatoxins and human liver cancer. IV. Incidence of primary liver cancer in two municipal populations of ThailandFood and Cosmetics Toxicology, 1972
- In-vitro Activation of Lymphocytes from Patients with Malignant DiseasesOncology, 1971
- MYCOTOXINS OTHER THAN AFLATOXINS: TUMOR-PRODUCING POTENTIAL AND POSSIBLE RELATION TO HUMAN DISEASEAnnals of the New York Academy of Sciences, 1970
- MYCOTOXINS IN APLASTIC AND PROLIFERATIVE BLOOD-DISEASESThe Lancet, 1970
- The Significance of Leukemia ClustersHospital Practice, 1968