THE EFFECT OF ANTIMICROBIAL AGENTS ON THE BINDING OF BILIRUBIN BY ALBUMIN

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Abstract
Summary: The effect of antibiotics, on the albumin binding capacity was studied by adding various concentrations of each drug in a standard solution of crystalline human serum albumin 4 g/ 100 ml, according to method of Porter & Waters (8). We found significant depression (above 25 %) of binding capacity of the albumin after addition of the following drugs in concentrations reaching therapeutical blood levels: Novobiocin and Sulfonamides (Elkosin, Sulfexin, Gantrisin).Moderate depression (11‐25 %) was observed with the following drugs: Oxacillin, Ce‐phalothin and Rifamycin.Little or no decrease of the albumin binding capacity was found after the addition of the following drugs: Penicillin, Penetracin, Methi‐cillin (Staphcillin, Celbenin) Ampicillin, (Pen‐trexyl, Penbritin), Cloxacillin, Lincomycin, Cephaloridin, Streptomycin, Colimycin, Chloramphenicol succinate, Erythromycin, Tetra‐cyclin hydrochloride, Pyrolidynomethyl‐tetra‐cyclin and Oxytetracyclin.

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