Figure 4 from Defining Non–small Cell Lung Cancer Tumor Microenvironment Changes at Primary and Acquired Immune Checkpoint Inhibitor Resistance Using Clinical and Real-World Data

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Abstract
Analysis of the TME after monochemotherapy in the Tempus cohort 3 and SU2C-NSCLC cohorts. A, Volcano plot of differential expression analysis for 12 patients treated with platinum-based chemotherapy within Tempus cohort 3. B, Box plot of IFNγ signature expression before and after platinum therapy in 12 patients with paired biopsies. C, Box plot of the IFNγ signature by prior platinum-based therapy history in the SU2C-NSCLC cohort. D, Schematic of PD-L1 IHC class switching observed in Tempus cohort 3 by treatment class (ICI vs. non-ICI).