Low-Molecular Weight Proteins as Markers for Glomerular Filtration Rate
Authors:
Open Access
- 1 December 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 47 (12) , 2179-2180
Abstract
Inulin clearance (CIn) is the usual gold standard for evaluating glomerular filtration rate (GFR), but technical difficulties and patient inconvenience prevent its widespread use ( 1). The most commonly used marker for GFR is serum creatinine, but muscle wasting and tubular secretion may lead to overestimation of GFR ( 2)( 3). Serum concentrations of the low-molecular weight proteins cystatin C (CysC) ( 4), β2-microglobulin (B2M) ( 5)( 6), and β-trace protein (BTP) ( 7) maybe useful alternatives for detecting reduced GFR, but no study to date has compared all of these proteins directly to CIn.Keywords
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