Prospective Study of Cytomegalovirus Infection in Pregnancy

Authors:
  • HSH. Stern
    H. Stern
  • STS. M. Tucker
    S. M. Tucker
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Abstract
In a prospective study of cytomegalovirus infection in 1,040 pregnant women in London 319 (42%) of the white Englishwomen but only 28 (10%) of the immigrant Asian women were without antibodies at the onset of pregnancy. Out of 254 susceptible white women and 16 susceptible Asian women 8 (3%) and 3 (16%) respectively experienced primary infection during the course of pregnancy. The overall incidence of fetal infection after primary infection in the mother was almost 50%, and was higher in early pregnancy. One out of the five infected infants was found to be mentally retarded. Reactivation of latent infection was recognized in 0·7-2·9% of pregnant women; this occurred without involving the fetus.

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