Spontaneous Ocular Surface Inflammation and Goblet Cell Disappearance in IκBζ Gene-Disrupted Mice

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Abstract
Purpose. The ocular surface epithelium is part of the mucosal defense system. Because transcription factor NF-κB in mucosal epithelial cells plays a central role in regulating the genes that govern the onset of mucosal inflammatory responses, we examined the role of a regulator of NF-κB, IκBζ, in murine ocular surface inflammation.