Supplementary Figure S4 from ISL1: A Novel Neuroendocrine Subtype in Small Cell Lung Cancer Predicts Durable Response to Lurbinectedin

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Abstract
Heatmap of Differentially Expressed Genes Between ISL1 “High” and ISL1 “Low” SCLC Cell Lines Following Lurbinectedin Treatment. Select genes differentially expressed between ISL1 “high” lines (H209 and H187) and ISL1 “low” lines (H82 and SHP77) following 24 hours lurbinectedin treatment are mapped by log fold change (LogFC). Changes in MYC paralog expression are additionally mapped. *, P < 0.05, **, P < 0.01, ***, P < 0.001, ****, P < 0.0001.