Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections
Open Access
- 9 October 2012
- journal article
- editorial
- Published by Springer Nature in The EMBO Journal
- Vol. 31 (21) , 4100-4102
Abstract
Antigen recognition induces T cells to polarize towards antigen presenting cells (APC) generating an organized cell interface named the immunological synapse. T‐cell microtubules (MTs) reorient the MT‐organizing centre (MTOC) to the immunological synapse central region, while MT irradiate towards the synapse periphery. [Martín‐Cófreces et al (2012)][1] describe in this issue that the MT plus‐end‐binding protein 1 (EB1) interacts with TCR cytosolic regions and mediate the organization of an immunological synapse fully functional to transduce activation signals. [1]: #ref-8Keywords
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