EFFECT OF VEHICLE ON PILOCARPINE‐INDUCED OCULAR HYPOTENSION

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Abstract
The effect of 1.4% polyvinyl alcohol and castor oil vehicles on pilocarpine‐induced hypotension was studied in 50 patients with open‐angle glaucoma. Diurnal tension curves showed that the mean intraocular pressure was lower and the maximum diurnal variation smaller during the treatment with oily drops of 2% and 4% pilocarpine instilled 2–3 times daily than when 2% and 4% pilocarpine in polyvinyl alcohol was instilled 3–4 times daily. The differences were statistically significant. In long‐term treatment no marked pilocarpine tolerance developed in cases treated with oily drops of pilocarpine. It is concluded that in the treatment of patients with open‐angle glaucoma, the hypotensive effect of pilocarpine in an oily vehicle instilled 2–3 times daily is greater and more even than that of pilocarpine of corresponding strength in polyvinyl alcohol administered 3–4 times daily.

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