Combination antimicrobial therapy to manage resistance

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Abstract
The concurrent use of multiple antimicrobials to treat patients is common in clinical practice. Combination therapy is used for many reasons, the majority of which have little to do with antimicrobial resistance [ 1]. However, combination therapy impacts both the likelihood and the nature of resistance evolution, thus it has been a major focus of ‘resistance management strategies’ aimed at alleviating the global antimicrobial resistance crisis.