A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis
- 22 January 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (4) , 999-1002
Abstract
Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of β-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and 19F-BAY94-9172.Keywords
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