Antioxidant activity of the methanol extract of Ferula assafoetida and its essential oil composition

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Abstract
The antioxidant activity of the aerial parts of Ferula assafoetida was determined by employing various in vitro assay systems. IC50 for DPPH radical-scavenging activity was 380 ± 12 mg ml-1. The extracts showed good nitric oxide-scavenging activity (IC50 was 270 ± 3) and Fe2+ chelating ability (IC50 was 0.57 ± 0.02 mg ml-1). The peroxidation inhibition (antioxidant activity) of the extracts exhibited values from 82% (at 24 hrs) and 88% (at 72 hrs). The extract exhibited a fairy weak reducing power at 25-800 μg ml-1 of extracts which was not comparable with Vitamin C (p < 0.001). The tested extracts exhibited very low antioxidant activity. In addition, the chemical composition of the essential oil of the aerial parts was determined. The major compounds were phenol, 2-methyl-5-(1-methyl ethyl) (18.2 %), α.-Bisabolol (10.4%) and Arsine triethyl (8.7 %). Total phenol compounds, as determined by the Folin Ciocalteu method, were 94.8 ± 5.9 mg gallic acid equivalent/g of extract powder and the total flavonoid content (by AlCl3 method) was 90.9 ± 6.3 mg quercetin equivalent/g of extract powder.

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