CORTICOSTEROIDS IN THE TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA
Authors:
- M L LorenMLM L Loren
- H ChaiHCH Chai
- P LeungPLP Leung
- C RohrCRC Rohr
- A M BrennerABA M Brenner
- 1 January 1980
- journal article
- research article
- Vol. 45 (2) , 67-71
Abstract
In a 72-h double-blind study, 16 moderately to severely asthmatic subjects received either oral prednisone 2 mg/kg per day or placebo in addition to their regular medication as treatment for an acute exacerbation of asthma. The group receiving prednisone demonstrated significant increases in the PEFR [peak expiratory flow rate] and decreased need for beta-2 agonist nebulization or injections the first 12 h of the study period, and these improvements were maintained over the 72 h. The placebo-treated group showed minimal reduction in nebulization and injection requirements and minimal increase in PEFR. Oral prednisone was effective in controlling acute exacerbations of asthmatic symptoms.Keywords
This publication has 6 references indexed in Scilit:
- Treatment of Status Asthmaticus in Children With High Doses and Conventional Doses of MethylprednisolonePediatrics, 1978
- Comparison between Simple Nebulization and Intermittent Positive-Pressure in Asthmatic Children with Severe BronchospasmChest, 1977
- Comparison of subcutaneous terbutaline with epinephrine in the treatment of asthma in childrenJournal of Allergy and Clinical Immunology, 1977
- PHYSIOLOGIC EFFECT OF AN INTRAVENOUS GLUCOCORTICOID IN BRONCHIAL-ASTHMA1976
- The Time-Course of Response to Prednisolone in Chronic Bronchial AsthmaClinical Science, 1974
- Meticorten (prednisone) and meticortelone (prednisolone) in the treatment of allergic disordersJournal of Allergy, 1956