Exploring cell mechanobiology: sensors and mechanotransduction
Authors:
- Wei LiuWLWei Liu
- Yu-Ting DuYDYu-Ting Du
- Xin-Xin XuXXXin-Xin Xu
- Yixin LiuYLYixin Liu
- Baohong LiuBLBaohong Liu
- Yan-Jun LiuYLYan-Jun Liu
Open Access
- 18 March 2025
- journal article
- Published by Science China Press., Co. Ltd. in Chinese Science Bulletin
- Vol. 70 (15) , 2249-2262
Abstract
生物体通过感知环境并做出适应性反应来维持其生命活动,细胞在此过程中展现出感知与响应微环境信号的能力。除生物化学信号外,生物力学信号作为微环境的重要组成部分,近年来受到广泛关注,对细胞功能及生物体稳态至关重要。本文总结了微环境中的力学信号及其体外模拟重构方法,文章详细讨论了生物力学感受器的分类,包括酶介导型、转录因子响应型、离子通道型以及其他类型,并探讨了它们在感知力学刺激和信号转导中的作用。特别强调了细胞核在力学信号感受和传递中的重要作用,以及新型研究工具和技术在模拟体内力学环境中的应用前景。最后,文章展望了生物力学感受器研究的发展趋势,指出了深入理解生物力学感知机制对于疾病治疗和组织工程的重要意义。Keywords
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