Association of Vascular Cell Adhesion Molecule‐1 Expression in Colonic Mucosa With Mucosal Inflammation and Subsequent Relapse in Patients With Ulcerative Colitis

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Abstract
Background and Aim: The association between vascular cell adhesion molecule‐1 (VCAM‐1) expression and intestinal mucosal inflammation and between VCAM‐1 expression and the clinical course in patients with ulcerative colitis (UC) remains unclear. Therefore, we investigated not only the association between mucosal VCAM‐1 expression and mucosal inflammation but also its association with subsequent relapse in UC patients with clinical remission.Methods: Fifty‐eight patients with UC in clinical remission and 16 patients in clinical active who visited Kyoto Prefectural University of Medicine for a 2‐year follow‐up period were included. VCAM‐1 expression was compared between patients who subsequently relapsed and those who remained in remission, and it was examined in relation to endoscopic findings, histological activity, and cytokine expression. We also investigated the expression of mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1).Results: VCAM‐1 was associated with clinical disease activity and endoscopic severity and was significantly elevated in histologically active mucosa compared with inactive mucosa. VCAM‐1 expression co‐localized with MAdCAM‐1 in the mucosal and submucosal microvessels of the colon and was significantly higher in the relapse group than in the remission group. Similar results were observed for MAdCAM‐1 expression. VCAM‐1 expression levels were also closely correlated with those of several other cytokines.Conclusions: VCAM‐1 expression in the colonic mucosa of patients with UC is associated with mucosal inflammation and subsequent relapse. These results suggest that VCAM‐1 may serve as a marker for relapse and therapeutic effectiveness in UC, and that treatment targeting α4 integrin is efficient and rational.

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