Abstract
Defects in different genes underlie the many kinds of genetic deafness. In this issue, [ Vahava et al .][1] report that a mutation in the transcription factor POU4F3 is the cause of deafness in a large Israeli family. In her commentary, Steel discusses how the malfunctioning of this transcription factor may lead to progressive deafness, with onset at age 18. [1]: http://www.sciencemag.org/cgi/content/short/279/5358/1950

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