Quantitative Fourier transform near-infrared spectroscopy in the quality control of solid pharmaceutical formulations

Authors:
  • GCGiuseppe Ceramelli
    Giuseppe Ceramelli
  • PCPiero Corti
    Piero Corti
  • MMMaurizio Massacesi
    Maurizio Massacesi
  • PPPiero Luigi Perruccio
    Piero Luigi Perruccio
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Abstract
In this study we investigated the capacities of near-infrared spectroscopy equipment with Fourier transform spectral analysis and an optical fibre probe. The equipment was tested for quantitative analysis during pharmaceutical production of powders containing benzydamine hydrochloride and tricetol (a p-toluene sulfonate analogue of cetyltrimethylammonium bromide), pills containing ibuprofen and tablets containing paracetamol.