Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction

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Abstract
Obesity has a strong impact on the pathogenesis of cardiovascular disease, which raises enthusiasm to understand how excess adiposity causes vascular injury. Adipose tissue is an essential regulator of cardiovascular system through its endocrine and paracrine bioactive products. Obesity induces endothelial dysfunction, which often precedes and leads to the development of cardiovascular diseases. Connecting adipose tissue-endothelial cell interplay to endothelial dysfunction may help us to better understand obesity-induced cardiovascular disease. This Mini Review discussed (1) the general interactions and obesity-induced endothelial dysfunction, (2) potential targets, and (3) the outstanding questions for future research.
Funding Information
  • National Institutes of Health (R01HL-130845)
  • American Heart Association (10SDG2600164, 14BGIA20030027)
  • American Diabetes Association (1-12-JF-58)
  • Oklahoma Center for the Advancement of Science and Technology (HR11-200, HR14-062, HR17-046)

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