Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands
- 15 May 2013
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 15 (11) , 2876-2879
Abstract
A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C–N and C–O bond-forming processes is also described.Keywords
This publication has 16 references indexed in Scilit:
- C-O Cross‐Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic AlcoholsAngewandte Chemie International Edition, 2012
- Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical UreasJournal of the American Chemical Society, 2012
- Synthesis of Imidazo[4,5-b]pyridines and Imidazo[4,5-b]pyrazines by Palladium Catalyzed Amidation of 2-Chloro-3-amino-heterocyclesOrganic Letters, 2012
- A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild ConditionsOrganic Letters, 2011
- Completely N1-Selective Palladium-Catalyzed Arylation of Unsymmetric Imidazoles: Application to the Synthesis of NilotinibJournal of the American Chemical Society, 2011
- A New Palladium Precatalyst Allows for the Fast Suzuki−Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic AcidsJournal of the American Chemical Society, 2010
- Highly Regioselective Palladium-Catalyzed Direct Arylation of Oxazole at C-2 or C-5 with Aryl Bromides, Chlorides, and TriflatesOrganic Letters, 2010
- Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl FluoridesScience, 2009
- An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chloridesTetrahedron, 2009
- The Selective Reaction of Aryl Halides with KOH: Synthesis of Phenols, Aromatic Ethers, and BenzofuransJournal of the American Chemical Society, 2006