Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

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Abstract
Introduction The aim of this study was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women with type 1 diabetes. Material and methods An observational study of 198 pregnant women with type 1 diabetes. 25‐Hydroxy‐Vitamin D and HbA1c were measured in blood samples in early (median 8 weeks, range 5–14) and late (34 weeks, range 32–36) pregnancy. Kidney involvement (microalbuminuria or nephropathy) at inclusion, smoking status at inclusion, preterm delivery (p = 0.04). After adjustment for preexisting kidney involvement, HbA1c in late pregnancy and smoking the association became nonsignificant (adjusted odds ratio 1.8; 95% confidence interval 0.8–3.7). Preeclampsia developed in 11% of women with vitamin D insufficiency vs. 6% of the remaining women (crude odds ratio 1.8; 95% confidence interval 0.9–4.1, p = 0.25). Conclusion In women with type 1 diabetes, preterm delivery was twice as frequent in women with vitamin D insufficiency in late pregnancy in crude analysis, but in this small study, low vitamin D was not independently associated with preterm birth or preeclampsia.
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  • Rigshospitalet

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