A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575.

Authors:
  • TSToru Sasaki
    Toru Sasaki
  • HWHiro-Omi Watabe
    Hiro-Omi Watabe
  • SMShinji Miyadoh
    Shinji Miyadoh
  • MNMieko Nagasawa
    Mieko Nagasawa
  • TSTakashi Shomura
    Takashi Shomura
  • MSMasaji Sezaki
    Masaji Sezaki
  • SIShigeharu Inouye
    Shigeharu Inouye
  • SKShinichi Kondo
    Shinichi Kondo
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Abstract
A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and 13C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.