Metabolites of Vitamin D3 and Their Biologic Activity

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Abstract
The metabolism of vitamin D3 has been studied after intravenous injection of 10 IU [1, 2-3H]-vitamin D3 to vitamin D-deficient rats. A new chromatographic system achieved the separation of unchanged vitamin D and 11 radioactive metabolites of which only one (25-hydroxycholecalciferol) exhibits intense antirachitic activity. An important proportion of the radioactivity in bones and small intestine is represented by this active metabolite. By way of contrast, liver and kidneys accumulate selectively unchanged D3. Plasma as expected contains large amounts of 25-hydroxycholecalciferol.

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