Human cancer germline antigen-specific cytotoxic T cell—what can we learn from patient
Authors:
Open Access
- 25 May 2020
- journal article
- review article
- Published by Springer Nature in Cellular & Molecular Immunology
- Vol. 17 (7) , 684-692
Abstract
In this review, we will highlight the importance of cancer germline antigen-specific cytotoxic CD8+ T lymphocytes (CTL) and the factors affecting antitumor CTL responses. In light of cancer immunotherapy, we will emphasis the need to further understand the features, characteristics, and actions of modulatory receptors of human cancer germline-specific CTLs, in order to determine the optimal conditions for antitumor CTL responses.Keywords
Funding Information
- RCUK | Medical Research Council
This publication has 145 references indexed in Scilit:
- Statistical inference of the generation probability of T-cell receptors from sequence repertoiresProceedings of the National Academy of Sciences, 2012
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in CancerNew England Journal of Medicine, 2012
- Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patientsProceedings of the National Academy of Sciences, 2012
- HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8+T lymphocytesProceedings of the National Academy of Sciences, 2011
- Improved Survival with Ipilimumab in Patients with Metastatic MelanomaNew England Journal of Medicine, 2010
- Anti-CTLA-4 therapy results in higher CD4 + ICOS hi T cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissuesProceedings of the National Academy of Sciences, 2009
- Genome-wide analysis of cancer/testis gene expressionProceedings of the National Academy of Sciences, 2008
- The many important facets of T-cell repertoire diversityNature Reviews Immunology, 2004
- Tumor necrosis factor signalingCell Death & Differentiation, 2003
- T-cell antigen receptor genes and T-cell recognitionNature, 1988