Estimating Unbound Volume of Distribution and Tissue Binding by In Vitro HPLC-Based Human Serum Albumin and Immobilised Artificial Membrane-Binding Measurements
Authors:
- Klára L. ValkóKVKlára L. Valkó
- Shenaz B. NunhuckSNShenaz B. Nunhuck
- Alan P. HillAHAlan P. Hill
- 1 March 2011
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 100 (3) , 849-862
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Improving Compound Quality through in vitro and in silico Physicochemical ProfilingChemistry & Biodiversity, 2009
- Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein BindingJournal of Pharmaceutical Sciences, 2008
- Physiochemical drug properties associated with in vivo toxicological outcomesBioorganic & Medicinal Chemistry Letters, 2008
- High-Throughput Screening of Drug−Brain Tissue Binding and in Silico Prediction for Assessment of Central Nervous System Drug DeliveryJournal of Medicinal Chemistry, 2007
- The importance of plasma protein binding in drug discoveryExpert Opinion on Drug Discovery, 2007
- Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distributionJournal of Chromatography A, 2004
- Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein bindingJournal of Pharmaceutical Sciences, 2003
- A Comparison of Physiochemical Property Profiles of Development and Marketed Oral DrugsJournal of Medicinal Chemistry, 2003
- Drug-like properties and the causes of poor solubility and poor permeabilityJournal of Pharmacological and Toxicological Methods, 2000
- Effect of Altered Plasma Protein Binding on Apparent Volume of DistributionJournal of Pharmaceutical Sciences, 1979