Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic a-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation

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Abstract
Reaction of aromatic a-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf)2 following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H2O at 85 °C) leads to 1,4-disubstituted 1,2,3-triazoles as the final products after simple filtration.