Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms
Open Access
- 15 June 2023
- journal article
- research article
- Published by American Society for Microbiology in Microbiology Spectrum
- Vol. 11 (3) , e0313222
Abstract
Bacterial heptose metabolites, intermediates of lipopolysaccharide (LPS) biosynthesis, are novel microbe-associated molecular patterns (MAMPs) that activate proinflammatory signaling. In the gastric pathogen Helicobacter pylori , heptoses are transferred into host cells by the Cag type IV secretion system, which is also involved in carcinogenesis.Keywords
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Funding Information
- Deutsche Forschungsgemeinschaft (SFB 900)
- Deutsches Zentrum für Infektionsforschung (06.809)
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