Hierarchical Ag-Doped Hydroxyapatite Coatings on TiO2 Nanotubes Formed on Ti-407 Alloy: Antibacterial Evaluation Against Escherichia coli
Authors:
- Angie P. Tamayo-JimenezATAngie P. Tamayo-Jimenez
- Frank E. Melendez-AnzuresFrank E. Melendez-Anzures
- Maria P. Barron-GonzalezMBMaria P. Barron-Gonzalez
- Enrique M. Lopez-CuellarELEnrique M. Lopez-Cuellar
- Yadira Quiñones-GutierrezYQYadira Quiñones-Gutierrez
- Javier A. Garza-GuajardoJGJavier A. Garza-Guajardo
- Azael Martinez-De la CruzACAzael Martinez-De la Cruz
Open Access
- 11 December 2025
- conference paper
- Published by MDPI AG in Materials Proceedings
- Vol. 28 (1) , 4
Abstract
Postoperative infections in orthopedic implants remain a major complication, particularly in open fractures, where early bacterial colonization and the limited bioactivity of titanium alloys hinder osseointegration. This study reports a hierarchical coating synthesized in situ on Ti-407 alloy, integrating bioactive and antibacterial functions. TiO2 nanotube arrays were formed by anodization and subsequently functionalized by sequential electrodeposition of Ag nanoparticles and doped hydroxyapatite (HA) (Ca, P, Mg, Zn). SEM/EDS confirmed uniform coatings with a Ca/P ratio near stoichiometric HA (1.61). Agar diffusion assays against E. coli ATCC® 25922™ revealed well-defined inhibition zones, confirming the antibacterial efficacy of the coatings. These findings highlight the potential of hierarchical coatings to enhance bone integration while reducing infection risk in orthopedic implants.Keywords
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