Synthèse de l'Ala1‐Ala6‐Arg8‐vasopressine et de l'Ala1‐Ala6‐Lys8‐vasopressine, ainsi que de la (déamino‐Ala)1‐Ala6‐Arg8‐vasopressine et de la (désamino‐Ala)1‐Ala6‐Lys8‐vasopressine
Authors:
- 1 January 1965
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 48 (8) , 1885-1898
Abstract
Ala1‐Ala6‐Arg8‐vasopressin, Ala1‐Ala6‐Lys8‐vasopressin, (Deamino‐Ala)1‐Ala6‐Arg8‐vasopressin and (Deamino‐Ala)1‐Ala6‐Lys8‐vasopressin were prepared by condensation of a tripeptide azide or, respectively, a propionyl‐dipeptide azide with a hexapeptide amide, both fragments having been synthesized by methods excluding racemization. These peptides represent analogues of arginine‐vasopressin, lysinevasopressin and of their deamino derivatives, in which the ring is open and the sulphur atoms are replaced by hydrogen atoms. The new peptides were found to be devoid of any biological activity and did not inhibit the corresponding natural hormones. The significance of this observation is discussed.Keywords
This publication has 28 references indexed in Scilit:
- Necessity of the disulfide bond of vasopressin for antidiuretic activityBiochemical and Biophysical Research Communications, 1964
- Synthèse de La Phe2‐Orn8‐vasopressine et de la Phe2‐oxytocine, deux analogues de la vasopressine doués d'une activité Pressorique sélectiveHelvetica Chimica Acta, 1964
- Synthese von Peptid‐Zwischenprodukten für den Aufbau eines corticotrop wirksamen Nonadecapeptids. I. Nϵ‐t‐Butyloxycarbonyl‐L‐lysin, Nϵ‐(Nϵ‐t‐Butyloxycarbonyl‐L‐lysyl)‐Nϵ‐t‐butyloxycarbonyl‐L‐lysin, Nϵ‐t‐Butyloxycarbonyl‐L‐lysyl‐L‐prolyl‐L‐valyl‐glycin und DerivateHelvetica Chimica Acta, 1961
- Enzymic inactivation of oxytocin. III. Desthiooxytocin and S,S'-dibenzyldihydrooxytocin as oxytocinase inhibitors and substratesCollection of Czechoslovak Chemical Communications, 1961
- t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1Journal of the American Chemical Society, 1960
- Relation entre l'activité physiologique de l'ocytocine et l'état de son pont disulfureBiochimica et Biophysica Acta, 1958
- New Amine-masking Groups for Peptide SynthesisJournal of the American Chemical Society, 1957
- Neues Verfahren zur Synthese von Peptiden des Arginins.Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1934
- Über ein allgemeines Verfahren der Peptid‐SyntheseBerichte der deutschen chemischen Gesellschaft (A and B Series), 1932
- Über Nitroclupein.Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1911