Sodium ions and the secretion of catecholamines

Authors:
  • PBP. Banks
    P. Banks
  • RBRosemary Biggins
    Rosemary Biggins
  • RBR. Bishop
    R. Bishop
  • BCB. Christian
    B. Christian
  • NCN. Currie
    N. Currie
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Abstract
1. Perfusion of bovine adrenal glands with a potassium‐free Tyrode solution results in an increased spontaneous release of catecholamines and an increased response to stimulation with carbamylcholine.2. Perfusion with a Tyrode solution containing 70 m M‐KCl causes a marked secretion of catecholamines and a subsequent inhibition of secretion in response to stimulation with carbamylcholine.3. Perfusion with sodium‐free media abolishes or severely reduces the secretory response of the gland to carbamylcholine and to 70 m M‐KCl although the basal secretion shows an initial rise.4. Perfusion with sodium‐deficient media permits some retention of the secretory response.5. A possible role for intracellular sodium ions in the secretion of catecholamines is discussed.

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