Distribution and classification of the extracellular matrix in the olfactory bulb

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Abstract
Extracellular matrix (ECM) became an important player over the last few decades when studying the plasticity and regeneration of the central nervous system. In spite of the established role of ECM in these processes throughout the central nervous system (CNS), only few papers were published on the ECM of the olfactory system, which shows a lifelong plasticity, synaptic remodeling and postnatal neurogenesis. In the present study, we have described the localization and organization of major ECM molecules, the hyaluronan, the lecticans, tenascin-R and HAPLN1 link protein in the olfactory bulb (OB) of the rat. We detected all of these molecules in the OB showing differences in the molecular composition, staining intensity, and organization of ECM between the layers and in some cases within a single layer. One of the striking features of ECM staining pattern in the OB was that the reactions are shown dominantly in the neuropil, the PNNs were found rarely and they exhibited thin or diffuse appearance Similar organization was shown in human and mice samples. As the PNN limits the neural plasticity, its rare appearance may be related to the high degree of plasticity in the OB.
Funding Information
  • OTKA (K115471)
  • Magyar Tudományos Akadémia (MTA-TKI 11008)
  • Hungarian Science Foundation (EFOP-3.6.3-VEKOP-16-2017-00009, 2017-1.2.1-NKP-2017-00002, FIKP-2018)
  • Deutsche Forschungsgemeinschaft (Mo2249/2-1, Mo2249/2-2, MO 2249/3–1)

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