EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684
Authors:
- 1 January 2001
- journal article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 31 (13) , 2029-2036
Abstract
An efficient synthesis of the 5-HT2C receptor agonist Org 37684 is presented. The synthesis utilises the regioselective demethylation of an arylether as the key step.Keywords
This publication has 8 references indexed in Scilit:
- Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in ratsEuropean Neuropsychopharmacology, 1998
- 5-HT 2C receptor activation decreases appetite and body weight in obese subjectsPsychopharmacology, 1997
- SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor AntagonistNeuropharmacology, 1997
- 5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in ratsEuropean Neuropsychopharmacology, 1996
- Multiple Serotonin Receptors: Opportunities for New Treatments for Obesity?Obesity Research, 1995
- Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptorsNature, 1995
- Molecular orbital calculations and carbon-13 NMR studies to explain a regiospecific demethylation of 3-alkyl-1,2-dimethoxybenzenesThe Journal of Organic Chemistry, 1984
- Regioselective cleavage of aromatic methyl ethers by methanesulphonic acid in the presence of methionineJournal of the Chemical Society, Perkin Transactions 1, 1977