Complete Response of Multiple Melanoma Brain Metastases after Treatment with Temozolomide

Authors:
  • BMB. Melichar
    B. Melichar
  • JZJ. Zizka
    J. Zizka
  • DHD. Hadzi-Nikolov
    D. Hadzi-Nikolov
  • JPJ. Petera
    J. Petera
Publisher website
Google Scholar
Abstract
Inoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare. A patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance. The present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.