A case of diffuse scleroderma successfully treated with high-dose intravenous immune globulin infusion

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Abstract
Sir, A 60-yr-old Japanese female visited our hospital in August of 2000 complaining of Raynaud's phenomenon. On physical examination, skin sclerosis was evident on the fingers, hands, forearms, upper arms, face, chest, abdomen, lower legs and the dorsum of the feet. The modified Rodnan total skin thickness score (TSS) [1] was 24. Nailfold bleeding and flexion contractions of the phalanges were also observed. She had no symptoms suggestive of other collagen diseases.