When the Failing, End-Stage Heart Is Not End-Stage
Authors:
- Dale G. RenlundDRDale G. Renlund
- Abdallah G. KfouryAKAbdallah G. Kfoury
- 2 November 2006
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 355 (18) , 1922-1925
Abstract
Heart failure is increasing in incidence and prevalence, is expensive to treat, and is associated with substantial morbidity and mortality.1 In the nomenclature of the guidelines of the American Heart Association and the American College of Cardiology, the majority of patients with heart failure are classified as having stage C heart failure, characterized by structural heart disease that is or has been symptomatic.2 Numerous drugs (e.g., angiotensin converting–enzyme [ACE] inhibitors or angiotensin-receptor blockers, beta-blockers, and aldosterone blockers) and electrophysiological devices may temporarily halt, slow, or even reverse the pathophysiological processes in patients with stage C heart failure. Reversion of the . . .Keywords
This publication has 11 references indexed in Scilit:
- Left Ventricular Assist Device and Drug Therapy for the Reversal of Heart FailureNew England Journal of Medicine, 2006
- Mechanical Unloading During Left Ventricular Assist Device Support Increases Left Ventricular Collagen Cross-Linking and Myocardial StiffnessCirculation, 2005
- Adult Cardiac Stem Cells Are Multipotent and Support Myocardial RegenerationCell, 2003
- Myocyte renewal and ventricular remodellingNature, 2002
- ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure)Circulation, 2001
- Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart FailureNew England Journal of Medicine, 2001
- Myocyte proliferation in end-stage cardiac failure in humansProceedings of the National Academy of Sciences, 1998
- Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian HeartCirculation Research, 1998
- Myocyte Recovery After Mechanical Circulatory Support in Humans With End-Stage Heart FailureCirculation, 1998
- Combined Oral Positive Inotropic and Beta-Blocker Therapy for Treatment of Refractory Class IV Heart FailureJACC, 1998