SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice
- 10 January 2018
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 61 (4) , 906-918
Abstract
Better understanding of how genetic and epigenetic components control beta cell differentiation and function is key to the discovery of novel therapeutic approaches to prevent beta cell dysfunction and failure in the progression of type 2 diabetes. Our goal was to elucidate the role of histone deacetylase sirtuin 6 (SIRT6) in beta cell development and homeostasis.Keywords
Funding Information
- National Institute of Diabetes and Digestive and Kidney Diseases (RO1-DK80157)
- San Antonio Nathan Shock Center of Excellence on Aging Biology (AG013319)
- San Antonio Claude D.Pepper Older Americans Independence Center (AG044271)
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