A Novel Versipelostatin Analogue, Versipelostatin F Isolated from Streptomyces versipellis 4083-SVS6
- 1 December 2008
- journal article
- Published by Springer Nature in The Journal of Antibiotics
- Vol. 61 (12) , 752-755
Abstract
A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC50 value of 0.3 μM, which is 10-times more potent compared with that of 1.Keywords
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